Protective effect of GuanXinShiWeiWan on isolated rat hearts with ischemia reperfusion injury / 中国生化药物杂志
Chinese Journal of Biochemical Pharmaceutics
; (6): 21-24, 2015.
Article
em Zh
| WPRIM
| ID: wpr-465201
Biblioteca responsável:
WPRO
ABSTRACT
Objective To investigate the protective effect of GuanXinShiWeiWan on ischemia reperfusion(I-R) injury rat.Methods 50 Wistar rats were randomly divided into normal group, model group, GuanXinShiWeiWan low ( 0.3 mg/kg ) and high ( 0.9 mg/kg ) dose group and positive group, each had 10 rats.Adopting the model of ischemia reperfusion injury of isolated rat hearts, the contents of SOD,MDA,LDH,CK and Ca2 +-ATP, Ca2 +-Mg2 +-ATP, Na +-K +-ATP in cardiac muscle tissue were tested and compared.Results Compared with model group, GuanXinShiWeiWan significantly improved the activities of SOD、Ca2 +-ATP,Ca2 +-Mg2 +-ATP and Na +-K +-ATP (P<0.05 or P<0.01) in cardiac muscle tissue which injured by ischemia reperfusion, while reducing markedly the contents of MDA,LDH,CK(P<0.05 or P<0.01).Conclusion GuanXinShiWeiWan can profect the cardiac muscle of ischemia reperfusion.
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Índice:
WPRIM
Idioma:
Zh
Revista:
Chinese Journal of Biochemical Pharmaceutics
Ano de publicação:
2015
Tipo de documento:
Article