Quantitative analysis of kidney on 3.0T 1H-MRS / 中国医学影像技术

ABSTRACT

Objective To analyze proton MR spectroscopy (1H-MRS) characteristics of kidney in vivo, and to investigate the changes and applications of metabolites of kidney on 3.0T MR. Methods Fifteen patients with renal cell carcinoma and 50 healthy volunteers underwent single-voxel PRESS sequence MR scan on 3.0T scanner. Results Satisfied spectra of 13 patients and 48 volunteers were obtained. There were four main groups resonance peak: cholesterol and the unsaturated parts of the olefinic region of fatty acids (Chol+Unsat), water, choline metabolites (Cho) and lipids (Lip). The ratio of the Chol+Unsat to Lip was 5-fold lower in renal cell carcinomas group than that in contrast group (F=4.764, P=0.04). Conclusion A number of chemical compounds pertaining to metabolism in kidney can be quantitative analyzed, which may offer assistance for diagnosis of renal cell carcinoma.