Advances in competing endogenous RNA modulation of cancer progression / 肿瘤研究与临床
Cancer Research and Clinic
; (6): 568-571, 2015.
Article
em Zh
| WPRIM
| ID: wpr-480060
Biblioteca responsável:
WPRO
ABSTRACT
Protein-coding transcriptome,pseudogenes,long non-coding RNAs and circular RNAs can act as competing endogenous RNA (ceRNA).ceRNA can crosstalk with each other through microRNA recognition elements (MRE),thus regulating the post-transcriptional gene expression.More and more evidences showed that ceRNA could form an extensive network of post-transcription regulation,keep the cell homeostasis and involve in the disease development and progression like tumorigenesis and cancer progression.Depending on up-regulation or down-regulation of different kinds of microRNA in different cells,ceRNA acts as either an oncogene or a tumor suppressor.ceRNA may have a great potential in cancer diagnosis and treatment.
Texto completo:
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Índice:
WPRIM
Idioma:
Zh
Revista:
Cancer Research and Clinic
Ano de publicação:
2015
Tipo de documento:
Article