Role of 1,25(OH)2 vitamin D3 and vitamin D receptor in chronic kidney kiseases / 国际儿科学杂志

ABSTRACT

1,25 (OH)2 D vitamin3 is the activated form of vitamin D in human body.Mediated by specific vitamin D receptor, 1,25(OH) 2 vitamin D3 plays an important role in many physiological and pathological process.In recent years, researches have shown that 1,25 (OH) 2 vitamin D3 can protect podocytes, inhibit the proliferation of mesenteric cells, regulate the apoptosis of mesenteric cells, anti-inflammation, and have negative effect in rennin-angiotensin system, so as to protect the renal function.This paper reviews the progress of the effect of 1,25(OH)2 vitamin D3 and vitamin D receptor in chronic renal disease.