Detection and identiifcation of serum biomarker for ganglioneuroblastoma in children / 临床儿科杂志
Journal of Clinical Pediatrics
; (12): 124-127, 2016.
Article
em Zh
| WPRIM
| ID: wpr-485852
Biblioteca responsável:
WPRO
ABSTRACT
Objective To build a more perfect serum protein ifngerprint models for early diagnosis of ganglioneuroblas-toma (GNB) in children. Methods Thirty children with GNB and 30 normal control children were recruited. Serum samples were collected. Nonspeciifc serum protein was detected and studied by MB-WCX processing, SELDI-TOF-MS mass spectrom-etry system and MALDI-TOF/TOF platform. Results Through the SELDL-TOX-MS processing, a peak at 5920 m/z protein markers, and the expression of the markers was high in GNB children (6180.6±2328), compared with normal control children (419.1±493.3), the difference was statistically signiifcant (P<0.05);MALDI-TOF/TOF platform showed that the protein with a peak at 5920 m/z is identiifed as ApoC-Ⅲ. Conclusions m/z peak of 5920 protein is suggested as speciifc biomarker of GNB in children, can provide signiifcant reference for early diagnosis of ganglioneuroblastoma, and prognostic monitoring.
Texto completo:
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Índice:
WPRIM
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
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Screening_studies
Idioma:
Zh
Revista:
Journal of Clinical Pediatrics
Ano de publicação:
2016
Tipo de documento:
Article