Correlation between promoter methylation of hMLH1 and DAPK genes and drug resistance of lung cancer / 肿瘤研究与临床
Cancer Research and Clinic
; (6): 207-209, 2016.
Article
em Zh
| WPRIM
| ID: wpr-489142
Biblioteca responsável:
WPRO
ABSTRACT
Drug resistance is one of the major obstacles for chemotherapy and targeted therapy in lung cancer with complex mechanisms.The researches have demonstrated that epigenetic changes are closely related to drug resistance of tumor.DNA methylation is an important epigenetic modification.In this paper, the relationships between hMLH1 promoter aberrant methylation and platinum-resistance, and DAPK promoter aberrant methylation and EGFR-TKI resistance in lung cancer will be briefly reviewed.
Texto completo:
1
Índice:
WPRIM
Idioma:
Zh
Revista:
Cancer Research and Clinic
Ano de publicação:
2016
Tipo de documento:
Article