Intravitreal Ranibizumab Injection Combined with Complex Trabeculectomy in Treatment of Neovascular Glaucoma / 医药导报

ABSTRACT

Objective To investigate the clinical efficacy of intravitreal ranibizumab injection combined with complex trabeculectomy in treatment of neovascular glaucoma. Methods Totally 38 patients(38 eyes) of neovascular glaucoma were divided into two groups of 19 cases in each randomly. Patients in treatment group were treateded with complex trabeculectomy after intravitreal injection 0. 05 mL ( 0.5 mg ) ranibizumab 4 - 7 days. Patients in control group were treateded with cyclocryotherapy. Visual acuity, intraocular pressure, iris neovascularization and complications were observed. Results The average intraocular pressure of preoperation and postoperation 1 month in treatment group were (6.5±1.7) kPa and (2.1±1.2) kPa.The difference of intraocular pressure before and after operation was significant. The average preoperative and postoperative intraocular pressure in control group were (6.7±1.9) kPa and (2.5±1.2) kPa . The postoprative intraocular pressure of treatment group was lower than that of control group, the difference was statistically significant( P< 0.05). Visual acuity and operative reaction after operation in treatment group were superior to those in control group. Conclusion Intravitreal injection of ranibizumab combined with complex trabeculectomy in treatment of neovascular glaucoma is safe and effective and worth in clinical application.