The impact of berberine on insulin resistance and cytokines in patients with schizophrenia / 天津医药
Tianjin Medical Journal
; (12): 1143-1146, 2016.
Article
em Zh
| WPRIM
| ID: wpr-498676
Biblioteca responsável:
WPRO
ABSTRACT
Objective To explore the impact of berberine on serum levels of insulin resistance and cytokines in schizophrenia patients treated with risperidone. Methods Sixty-four schizophrenia patients treated with risperidone were randomized to berberine group (n=31) and control group (n=33). The fasting plasma blood glucose (FBG) and fasting insulin (Fins) were detected before and after treatment in two groups. The homeostasis model assessment for insulin resistance (HOMA-IR) was calculated. The serum levels of interleukin (IL)-1β, IL-6, tumor necrosis factor-alpha (TNF-α) were evaluated by enzyme linked immunosorbent assay before and after the treatment. Results Compared with control group and pre-treatment group, the levels of FBG, Fins, HOMA-IR, IL-1β, IL-6 and TNF-α were significantly decreased after treatment in berberine group (P 0.05). There was positive correlation between HOMA-IR and IL-1β, IL-6 and TNF-α in berberine group (r=0.316, 0.351 and 0.401, P 1β, IL-6 and TNF-α levels in schizophrenia patients treated with risperidone. The HOMA-IR level is closely correlated with IL-1β, IL-6 and TNF-αlevels.
Texto completo:
1
Índice:
WPRIM
Tipo de estudo:
Clinical_trials
/
Prognostic_studies
Idioma:
Zh
Revista:
Tianjin Medical Journal
Ano de publicação:
2016
Tipo de documento:
Article