Research progress of a new therapeutic target in hepatocellular carcinoma glypican-3 / 中国药理学通报
Chinese Pharmacological Bulletin
; (12): 1486-1489, 2016.
Article
em Zh
| WPRIM
| ID: wpr-501576
Biblioteca responsável:
WPRO
ABSTRACT
Glypican-3 ( GPC3 ) plays very important role in the regulation of cell growth and differentiation in hepatocellular car-cinoma ( HCC ) . GPC3 is closely related to the occurrence and development of HCC. A dramatic elevation of GPC3 expression has been reported in a large proportion of HCC, which suggests that GPC3 is remarkably sensitive and specific to the diagnosis of HCC. GPC3 is a potential therapeutic target of HCC. This paper reviews the structure and function of GPC3, the progress of im-munotherapy based on GPC3 of HCC, and discusses the prospect of therapeutic target of liver cancer in the future.
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Índice:
WPRIM
Idioma:
Zh
Revista:
Chinese Pharmacological Bulletin
Ano de publicação:
2016
Tipo de documento:
Article