Study on therapeutic effect of Cefoselis sulfate versus Cefepime on stroke-associated pneumonia in elderly patients / 中华老年医学杂志
Chinese Journal of Geriatrics
; (12): 956-959, 2016.
Article
em Zh
| WPRIM
| ID: wpr-502431
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WPRO
ABSTRACT
Objective To explore the therapeutic effect of Cefoselis sulfate and Cefepime on the stroke-associated pneumonia in elderly patients.Methods 96 cases of stroke-associated pneumonia with positive pathogen were divided into two groups treated with Cefoselis versus Cefepime respectively.Body temperature,leukocyte count,arterial partial oxygen pressure,the serum level of C-reactive protein (CRP) and bacterial clearance rate were observed before and after the treatment.The cefoselis sulfate group (n =48) or the cefepime group (n =48) was treated with 2.0 g Cefoselis sulfate or 2.0 g Cefepime every 12 hours for 7 to 10 days.Results In post-treatment versus pretreatment,both two groups showed that clinical symptoms and inflammatory indicators were improved,and the patient's body temperature,white blood cell count and neutrophil cell count,hs-CRP and arterial partial oxygen pressure were significantly decreased (all P<0.05).Arterial partial oxygen pressure was better in post-versus pre-treatment (P<0.05).The total effective rate was 87.5% in Cefoselis sulfate group and 83.3% in cefepime group (P > 0.05).The bacterial clearance rate was higher (89.6%) in Cefoselis sulfate groups than in cefepime groups (67.9%) (P<0.05).In posttreatments of Cefoselis sulfate groups versus Cefepime groups,white blood cell count and neutrophil cell count,hs-CRP and arterial partial oxygen pressure showed no statistically significant differences (all P > 0.05).Conclusions Compared with Cefepime,Cefoselis has the similar anti-infection efficacy in the treatment of stroke-associated pneumonia.While,the bacterial clearance rate and the total effective rate are better in cefoselis group than in Cefepime group.
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Idioma:
Zh
Revista:
Chinese Journal of Geriatrics
Ano de publicação:
2016
Tipo de documento:
Article