Mechanism of drug resistance of Pseudomonas aeruginosa / 中国生化药物杂志

ABSTRACT

Pseudomonas aeruginosa exhibits an inherently reduced susceptibility to most antibiotics compared with most other Gram-negative bacterial species because its low outer membrane permeability and the multiple ways in which P.aeruginosa can become drug-resistant.Pseudomonas aeruginosa has joined the “super bacteria”.Recent researches, using mutant library screening, microarray technology, and mutation frequency analysis have demonstrated that antibiotics themselves can induce very large groups of genes in vivo growth conditions or complex adaptation conditions ( for example, biofilm growth or swarming motility), resulting in resistance as well as new forms of adaptive resistance.