The Levels of Cortisol and Oxidative Stress and DNA Damage in Child and Adolescent Victims of Sexual Abuse with or without Post-Traumatic Stress Disorder
Psychiatry Investigation
; : 616-621, 2016.
Article
em En
| WPRIM
| ID: wpr-50901
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE:
The aim of this study was to investigate whether cortisol and oxidative stress levels and DNA damage differ between individuals who developed PTSD or not following a sexual trauma.METHODS:
The study included 61 children aged between 5 and 17 years who sustained sexual abuse (M/F 18/43). The patients were divided into two groups patients with PTSD and patients without PTSD based, based on the results of a structured psychiatric interview (K-SADS-PL and CAPS-CA). Cortisol, glutathione peroxidase (GPx), superoxide dismutase (SOD), coenzyme Q, 8-Hydroxy-2-Deoxyguanosine (8-OHdG) were all evaluated by the ELISA method.RESULTS:
Our evaluation revealed a diagnosis of PTSD in 51% (n=31) of victims. There was no significant difference between the groups with or without PTSD in terms of cortisol, GPx, SOD, coenzyme Q, and 8-OHdG levels. There was no correlation between CAPS scores and GPx, SOD, coenzyme Q, and 8-OHdG levels between patients with or without PTSD. In patients with PTSD, both cortisol and 8-OHdG levels decreased with increasing time after trauma, and there was no significant correlation with cortisol and 8-OHdG levels in patients without PTSD.CONCLUSION:
Although the present study did not find any difference between the groups in terms of 8-OHdG concentrations, the decreases in both cortisol and 8-OHdG levels with increasing time after trauma is considered to indicate a relationship between cortisol and DNA damage.Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Delitos Sexuais
/
Transtornos de Estresse Pós-Traumáticos
/
Superóxido Dismutase
/
Dano ao DNA
/
DNA
/
Ensaio de Imunoadsorção Enzimática
/
Hidrocortisona
/
Ubiquinona
/
Estresse Oxidativo
/
Diagnóstico
Tipo de estudo:
Diagnostic_studies
/
Qualitative_research
Limite:
Adolescent
/
Child
/
Humans
Idioma:
En
Revista:
Psychiatry Investigation
Ano de publicação:
2016
Tipo de documento:
Article