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Research on preventative role of Nrf2 in kidney diseases / 中国药理学通报
Chinese Pharmacological Bulletin ; (12): 301-305, 2017.
Article em Zh | WPRIM | ID: wpr-510569
Biblioteca responsável: WPRO
ABSTRACT
Nrf2,a key transcriptional factor in regulating endog-enous antioxidant signaling pathway,maintains the redox bal-ance by controlling the expression of a battery of antioxidant en-zymes,phase-Ⅱ detoxification enzymes and phase-Ⅲ transport-ers.Furthermore,Nrf2 regulates inflammation.Recent resear-ches have confirmed that Nrf2 provides a vital physiological role in kidney diseases,activation of Nrf2 enhances the antioxidant and anti-inflammatory ability in cellular and tissue levels,thusalleviates renal injury.Here,this article aims to summarize the protective effect of Nrf2 on various models of kidney impairment and explore the potential of Nrf2 as a therapeutic target to pre-vent kidney diseases.
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Texto completo: 1 Índice: WPRIM Idioma: Zh Revista: Chinese Pharmacological Bulletin Ano de publicação: 2017 Tipo de documento: Article
Texto completo: 1 Índice: WPRIM Idioma: Zh Revista: Chinese Pharmacological Bulletin Ano de publicação: 2017 Tipo de documento: Article