Hesperidin Attenuates Ultraviolet B-Induced Apoptosis by Mitigating Oxidative Stress in Human Keratinocytes
Biomolecules & Therapeutics
; : 312-319, 2016.
Article
em En
| WPRIM
| ID: wpr-51941
Biblioteca responsável:
WPRO
ABSTRACT
Human skin cells undergo pathophysiological processes via generation of reactive oxygen species (ROS) upon excessive exposure to ultraviolet B (UVB) radiation. This study investigated the ability of hesperidin (C28H34O15) to prevent apoptosis due to oxidative stress generated through UVB-induced ROS. Hesperidin significantly scavenged ROS generated by UVB radiation, attenuated the oxidation of cellular macromolecules, established mitochondrial membrane polarization, and prevented the release of cytochrome c into the cytosol. Hesperidin downregulated expression of caspase-9, caspase-3, and Bcl-2-associated X protein, and upregulated expression of B-cell lymphoma 2. Hesperidin absorbed wavelengths of light within the UVB range. In summary, hesperidin shielded human keratinocytes from UVB radiation-induced damage and apoptosis via its antioxidant and UVB absorption properties.
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Índice:
WPRIM
Assunto principal:
Pele
/
Queratinócitos
/
Linfoma de Células B
/
Espécies Reativas de Oxigênio
/
Apoptose
/
Estresse Oxidativo
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Citosol
/
Citocromos c
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Absorção
/
Membranas Mitocondriais
Limite:
Humans
Idioma:
En
Revista:
Biomolecules & Therapeutics
Ano de publicação:
2016
Tipo de documento:
Article