Effects of Chinese Drugs for Nourishing Yin and Clearing the Heat on Sex Hormone Regulation and Clinical Efficacy in Systemic Lupus Erythema tosus / 中华皮肤科杂志

ABSTRACT

Objective To investigate the effects of Chinese drugs for nourishing Yin and clearing the heat on regulation of sex hormones and clinical efficacy patients with SLE.Methods Fifty four active SLE patients with Yin deficiency were randomly divided into 2groups.Thirty patients in tr eatment group were treated with Pill of Wind-weed Phellodendron and Rehman nia(Zhibai Dihuang Wan)and Bolus for Replenishing Vital Ess ence(Da Buyin Wan)combined with western medicine for 2months,while 24patients in control group were treated with western medicine alone.Before and a fter treatment,the serum levels of f ollicle-stimulating hormone(FSH),luteinizing hormone,estradiol,pr ogesterone,testosterone,prolactin were measured by ELISA in 54patien ts,respec-tively.Before treatment the serum l evels of FSH,luteinizing hormone,estradiol,progesterone,testosterone,prolactin were measured in 30active SLEpatien ts without Yin deficiency and 25age-matched healthy controls simultaneously.Results The mean levels of FSH,luteinizing h ormone,estradiol were significant ly higher in patients with Yin de-ficiency than those without Yin deficiency and those in heathy controls(P