Effects of thymosin ?_1 on the development and maturation of thymocytes / 中国病理生理杂志
Chinese Journal of Pathophysiology
; (12)1989.
Article
em Zh
| WPRIM
| ID: wpr-522754
Biblioteca responsável:
WPRO
ABSTRACT
AIM:
To investigate the effect of Thymosin ? 1 on the development and matutation of thymocytes.METHODS:
The proportion of CD4+CD8+ thymocytes and the expression of smoothened (Smo) of the hedgehog (Hh)-signaling in CD4-CD8-thymocytes were examined to observe the effect of thymosin ? 1 on thymocyte development and matutation.RESULTS:
Flowcytometric analysis showed that thymosin ? 1 showed activity at a low dose of 30 ?g/kg, and 30 ?g/kg thymosin ? 1 accelerated the replenishment and maturation of thymocytes according to the expression of Smo of the Hh-signaling in CD4-CD8-thymocytes, the potent negative regulator of proliferative responses.CONCLUSION:
Thymosin ? 1 can accelerate thymocyte development from CD4-CD8- to CD4+CD8+.
Texto completo:
1
Índice:
WPRIM
Idioma:
Zh
Revista:
Chinese Journal of Pathophysiology
Ano de publicação:
1989
Tipo de documento:
Article