Effect of Oral Ambroxol on Pharmacokinetics of Aminophyllin / 中国药房

ABSTRACT

OBJECTIVE:To study whether there is interaction between ambroxol hydrochloride and amino?phylline.METHODS:16volunteer were randomly divided into trial group and control group.The blood concentration of amin_ ophylline was determinated with HPLC method,then the main parameters of pharmacokinetics of aminophylline were calculated with3p97software.RESULTS:The main parameters of pharmacokinetics of aminophylline in trial and control group were:K e (0.062?0.023)/h and(0.0905?0.013)/h;V(22.83?7.85)and(23.27?3.78)L;T 1/2 (12.51?4.2)and(7.77?0.89)h;AUC 0～21 (426.59?186.92)and(245.74?48.6)(mg?h)/L;CL(s)(23.17?9.83)and(34.84?6.00)ml/min respective?ly.CONCLUSION:Although ambroxol hydrochloride did not influence the distribution of aminophylline,but it could prolong the half time of aminophylline and increase the stagnation time of aminophylline in vivo.