Reduction of Streptomycin Ototoxicity by Tetramethylpyrazine and its Ionic Channel Mechanism / 听力学及言语疾病杂志
Journal of Audiology and Speech Pathology
; (6)1998.
Article
em Zh
| WPRIM
| ID: wpr-528990
Biblioteca responsável:
WPRO
ABSTRACT
Objective To observe the effect of tetraethylplyrazine(TMP) on outward K~+ channel of outer hair cells in guinea pig cochlea.Methods 60 guinea pigs were divided into 6 groups randomly in the experiment.Auditory brainstem response was used to monitor the change of ABR thresholds and patch clamp techniques to observe the effect of TMP on outward K~+ channel.Results TMP decreased the elevated ABR threshold caused by streptomycin. The TMP increased the amplitudes of calcium sensitive potassium channels (I_ K(Ca) ) and delayed outward potassium channels (IK) of outer hair cells of guinea pig cochlea.Conclusion The study indicates that TMP may act as a protective agent against ototoxicity of streptomycin. The amplitudes of I_ K(Ca) and IK of outer hair cells are increased by the TMP,suggesting the possible mechanisms of reducing ototoxicity.
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Índice:
WPRIM
Idioma:
Zh
Revista:
Journal of Audiology and Speech Pathology
Ano de publicação:
1998
Tipo de documento:
Article