Two different types of malignant fibrous histiocytomas from pet dogs
Journal of Veterinary Science
; : 169-171, 2009.
Article
em En
| WPRIM
| ID: wpr-54361
Biblioteca responsável:
WPRO
ABSTRACT
We describe 2 cases of malignant fibrous histiocytomas (MFHs) that spontaneously developed in young pet dogs. To classify these tumors, we applied a panel of antibodies (vimentin, desmin, alpha-SMA, and ED1) and Azan staining for collagen. The MFHs were most consistent with osteoclast-like giant and inflammatory cell types. The first case had positive staining for ED1 and vimentin, and given the osteoclast-like giant cells, calcification sites accompanying peripheral giant cell infiltrates. The latter case, the inflammatory cell type, exhibited a storiform-pleomorphic variant of neoplastic cells, including an ossifying matrix. MFHs are among the most highly aggressive tumors occurring in soft tissue sarcomas in elderly dogs; however, MFHs have been poorly studied from a diagnostic point of view. Herein, we describe the histologic and immunohistologic features of MFHs in detail, thus classifying the subtypes of these tumors.
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Texto completo:
1
Índice:
WPRIM
Assunto principal:
Neoplasias de Tecidos Moles
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Biópsia
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Imuno-Histoquímica
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Doenças do Cão
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Histiocitoma Fibroso Maligno
Limite:
Animals
Idioma:
En
Revista:
Journal of Veterinary Science
Ano de publicação:
2009
Tipo de documento:
Article