Experimental study on prevention of peridural adhesion after laminectomy with local different concentration mitomycin C / 中国矫形外科杂志
Orthopedic Journal of China
; (24)2006.
Article
em Zh
| WPRIM
| ID: wpr-544890
Biblioteca responsável:
WPRO
ABSTRACT
[Objective]To compare the effects of topical different concentration mitomycin C(MMC)in preventing postlaminectomy peridural adhesion.[Method]Laminectomies were performed at L1 in 40 rats.Cotton pads soaked either with 0.01 mg / ml(group L),0.05 mg /ml(group M),0.1 mg / ml(group H) MMC or saline(group C) were applied to the operative sites.The rats were killed 4 weeks after surgery.The specimens were prepared for determination of the degree of scar adhesion according to Rydell method,the content of Hydroxyproline(HOP),the area of peridural fibrosis and the count of fibroblasts.[Result]Dense peridural fibrosis with marked peridural adhesion showed in group C.No obvious adhesion formed in group H.In group M and L,peridural adhesion wasn't avoided.The content of HOP,the area of peridural fibrosis and the count of fibroblasts showed various degrees decrease in all MMC-treated groups.[Conclusion]Local application of 0.1 mg/ ml MMC may be a successful method of reducing postlaminectomy peridural fibrosis and completely avoided peridural adhesion.
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WPRIM
Idioma:
Zh
Revista:
Orthopedic Journal of China
Ano de publicação:
2006
Tipo de documento:
Article