Screening for down syndrome fetus by alpha-fetoprotein and beta human chorionic gonadotropin in maternal serum \r\n', u'
Journal of Medical Research
; : 1-4, 2007.
Article
em Vi
| WPRIM
| ID: wpr-549
Biblioteca responsável:
WPRO
ABSTRACT
Background: The fetus having risk for Down sydrome (DS) can be detected early by AFP, \u03b2hCG in maternal serum to detect the fetus having risk of Down sydrome. Objectives: Determining values of AFP, \u03b2hCG in maternal serum to detect the fetus having risk of DS. Subjects and method: Determining the concentration of AFP, \u03b2hCG in maternal serum of 591 pregnant with fetus \ufffd?12 weeks to detect the fetus having DS screening risk. The fetus are diagnosed DS by analysing chromosome from amniocyte and monitor up to the neonate. Then, finding out association between DS fetus and AFP, \u03b2hCG in maternal serum. Results: 75/591 of subjects screened were screen positive, 6/7 DS fetus associated withscreen positive, (cut off AFP \ufffd?0,75 MoM, \u03b2hCG \ufffd?2,2 MoM). Detection rate (DR) was 85,71%; false positive rate (FDR): 11,81%. Only base on AFP: DR was 71,43%; FDR: 11,81%. Only base on \u03b2hCG DR was 28,57%; FDR: 0,51%. Conclusion: DR base on AFP is higher than base on \u03b2hCG. If combining AFP and \u03b2hCG, DR is the highest. AFP is important role in screening DS fetus.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Diagnóstico Pré-Natal
/
Valor Preditivo dos Testes
/
Síndrome de Down
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
/
Screening_studies
Limite:
Pregnancy
Idioma:
Vi
Revista:
Journal of Medical Research
Ano de publicação:
2007
Tipo de documento:
Article