Changes in the expression of cytokines and apoptosis-related genes in children with infectious mononucleosis / 소아과
Korean Journal of Pediatrics
; : 1348-1357, 2009.
Article
em Ko
| WPRIM
| ID: wpr-55861
Biblioteca responsável:
WPRO
ABSTRACT
PURPOSE: The aims of this study were to identify the clinical characteristics and determine the changes in the expression of cytokines and apoptosis-related genes in children with infectious mononucleosis. METHODS: Serological examinations of 15 pediatric patients diagnosed with infectious mononucleosis were performed prospectively. Peripheral blood from the patients was used to compare the composition of T cell subsets, cytokines, Epstein-Barr virus (EBV) DNA, and the expression of apoptosis-related genes with those in 10 healthy children. RESULTS: Mean age of the patient group was 5.7+/-3.4 (range, 3-9) years, and the male-to-female ratio was 1.5:1. Fever, sore throat, pharyngitis/tonsillitis, and cervical lymph node enlargement were the most common symptoms and signs. The proportions of CD3+ T cells, CD8+ suppressor cells, and CD56+ natural killer (NK) cells were higher in the patient group than in the control group (P<0.01). The IL-2, IL-6, and interferon (IFN)-gamma levels were higher in the early symptomatic period (P<0.01). Mean amount of EBV DNA in the patients was 10(2.38) copies/microg, and the amount was the highest at the beginning of the symptomatic period and normalized during the convalescent phase. Bcl-2 expression increased during the initial phase, while Bax expression increased during the convalescent phase. Further, FasL expression increased 1 week after symptom presentation and decreased during the convalescent phase. There was no significant change in Fas expression. CONCLUSION: We analyzed the clinical characteristics and changes in the expression ofcytokines and apoptosis-related genes in the patients with infectious mononucleosis.
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Índice:
WPRIM
Assunto principal:
DNA
/
Linfócitos T
/
Faringite
/
Estudos Prospectivos
/
Citocinas
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Subpopulações de Linfócitos T
/
Interferons
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Interleucina-6
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Interleucina-2
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Apoptose
Tipo de estudo:
Observational_studies
/
Prognostic_studies
Limite:
Child
/
Humans
Idioma:
Ko
Revista:
Korean Journal of Pediatrics
Ano de publicação:
2009
Tipo de documento:
Article