Thyroid hormone resistance with H435L mutation in exon 10 of thyroid hormone receptor ? gene associated with Hashimoto's thyroiditis / 基础医学与临床

ABSTRACT

T),resulting in His to Leu(CAT→CTT) substituted at codon 435(H435L).No mutation was identified in the patient's parents.HT occurred in the patient during following-up.Conclusion H435L mutation in exon 10 of TR? gene leads to resistance to thyroid hormone.Meanwhile,consistent RTH might lead to HT.