Bone Mineral Density is an Independent Determinant of Left Ventricular Mass Index in the General Female Population
Korean Circulation Journal
; : 573-580, 2010.
Article
em En
| WPRIM
| ID: wpr-59733
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND AND OBJECTIVES:
Left ventricular hypertrophy (LVH) is a well known cardiovascular prognostic predictor. Osteoporosis has been suggested to be associated with cardiovascular disease. According to studies of primary hyperparathyroidism, a pathophysiological association between calcium metabolism and LVH has been suggested but is not yet fully understood. This study was performed to investigate the association between bone mineral density (BMD) and left ventricular mass index (LVMI) in a general population. SUBJECTS ANDMETHODS:
Data from 460 subjects among 543 subjects sampled from a general population in a rural area in Korea were analyzed. BMD, echocardiography, brachial-ankle pulse wave velocity (baPWV), carotid intima-media thickness (IMT) measurement as well as the measurements of blood pressure, blood chemistry and metabolic parameters were analyzed. BMD was measured using the Sahara Clinical Bone Sonometer (Hologic Inc., Mass., USA).RESULTS:
Age of the subjects was 59.4+/-12.4 years. Males were 42.2% (n=194). In a simple correlation analysis on female subjects, age and waist circumference showed negative correlation, and body mass index (BMI) showed positive correlation with BMD. However, only age showed negative correlation with BMD in male subjects. After adjusting baPWV and carotid IMT, we found that BMD was an independent determinant of LVMI in female subjects (beta=-13.703, p=0.016), but not in male subjects (beta=-1.235, p=0.841).CONCLUSION:
BMD is a consistent and independent determining factor of LVMI, BMI and carotid IMT in postmenopausal women.Palavras-chave
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Índice:
WPRIM
Assunto principal:
Osteoporose
/
Pressão Sanguínea
/
Ecocardiografia
/
Doenças Cardiovasculares
/
Índice de Massa Corporal
/
Densidade Óssea
/
Cálcio
/
Hipertrofia Ventricular Esquerda
/
África do Norte
/
Hiperparatireoidismo Primário
Tipo de estudo:
Prognostic_studies
Limite:
Female
/
Humans
/
Male
País/Região como assunto:
Africa
/
Asia
Idioma:
En
Revista:
Korean Circulation Journal
Ano de publicação:
2010
Tipo de documento:
Article