Clinical Observation of Candesartan Combined with Amlodipine Besylate in the Treatment of Elderly Hyper-tension / 中国药房

ABSTRACT

OBJECTIVE:To observe the clinical efficacy and safety of candesartan combined with amlodipine besylate in the treatment of elderly hypertension. METHODS:Totally 156 elderly patients with hypertension were randomly divided into control group and observation group. Patients in control group were orally given Amlodipine besylate tablets 5 mg in the morning,once a day. Patients in observation group were orally given Candesartan tablets 8 mg based on the treatment of control group,once a day. The course of both was 8 weeks. The clinical data was observed,including clinical efficacy,systolic blood pressure(SBP)and dia-stolic blood pressure(DBP)before and after treatment,fasting blood glucose(FPG),insulin resistance index(HOMA-IR),24 h urinary albumin total(mAlb),serum creatinine(SCr)and the incidence of adverse reactions. RESULTS:The total effective rate in observation group was significantly higher than control group;the HOMA-IR,mAlb and SCr in observation group were significant-ly lower than control group,with significant difference(P0.05). There were no obvious adverse reactions during treatment. CONCLUSIONS:Candesartan combined with amlodipine besylate has better efficacy than only amlodipine besylate in the treatment of elderly hypertension,with similar safety.