Association of IL-17F rs763780 and rs2397084 polymorphisms with rheumatoid arthritis:a Meta-analysis / 中国免疫学杂志

ABSTRACT

Objective:To explore the association between rheumatoid arthritis(RA)and two polymorphisms of interleukin-17(IL-17F)rs763780 and rs2397084.Methods: A systematic search of relevant studies was conducted in China National Knowledge Infrastructure,Wanfang Chinese Periodical Database,China Biology Medical Literature Database,Pubmed,Embase and Web of Science.Results: A total of 5 case-control studies including 1 174 RA cases and 966 health controls for rs763780 and 985 RA cases and 766 health controls for rs2397084 were included in this Meta-analysis.The results showed that rs763780 was significantly associated with increased susceptibility to RA(C vs.TOR=1.74,95%CI=1.01-2.98,P=0.04;CC vs.TTOR=3.17,95%CI=1.21-8.35,P=0.02;CT vs.TTOR=1.80,95%CI=1.21-2.66,P=0.004;CC+CT vs.TTOR=1.96,95%CI=1.35-2.83,P<0.001;CC vs.CT+ TTOR=2.97,95%CI=1.13-2.66,P=0.03).In subgroup analysis based on ethnicity,rs763780 was positively correlated with RA in Europeans.No significant association was found between rs2397084 and RA.Conclusion: The present study revealed that IL-17F rs763780 polymorphism is a risk factor of RA,while the association of rs2397084 with RA remains uncertain.