Effects of levosimendan on hemodynamics and HIF-1 activity in patients with coronary heart disease and heart failure / 中国基层医药

ABSTRACT

Objective To explore the effects of levosimendan on hemodynamics and activated level of HIF-1 in patients with coronary heart disease and heart failure.Methods 80 patients with coronary heart disease and heart failure in our hospital were selected as the research subjects,they were randomly divided into two group,40 cases in each group.The control group received routine treatment,the observation group was given conventional treatment combined with levosimendan.The clinical efficacy,the occurrence of adverse reactions,hemodynamic parameters and HIF-1 alpha activation level were compared between the two groups.Results The total effective rate in the observation group was 95.00％,which was higher than 80.00％ in the control group(x2 =4.114,P ＜0.05).After treatment,left ventricular ejection fraction(LVEF),stroke volume (SV),HIF-1 alpha activation levels in the observation group were (49.36 ± 3.65) ％,(76.29 ± 5.31) mL and (0.47 ± 0.15),compared with before treatment,LVEF and SV were significantly higher(t =14.998,10.267,all P ＜ 0.05),HIF-1 alpha activation level was significantly lower (t =9.624,P ＜ 0.05),and compared with the control group after treatment,the differences were statistically significant(t =8.264,4.726,4.411,all P ＜ 0.05).The two groups had no obvious adverse reactions.Conclusion Levosimendan in the treatment of coronary heart disease and heart failure has significant clinical efficacy,can effectively improve the hemodynamics and cardiac function in patients,also can inhibit HIF-1 alpha level,it is safe and reliable.