Diffusion kurtosis imaging in diagnosis of prostate carcinoma in peripheral zone / 局解手术学杂志

ABSTRACT

Objective To evaluate the application value of 3 main parameters of diffusion kurtosis imaging(DKI) in diagnosis of prostatic carcinoma in the peripheral zone.Methods Conventional MRI and DKI were performed in 40 patients with histological confirmed as prostatic carcinoma in the peripheral zone.The values of ADC,FA and MK were calculated in the patients' tumor center and normal areas of the peripheral zone,and compared by two samples t-test.ROC curve were carried out to analyze the ability of ADC,MK and FA in differentiating prostate carcinoma from normal tissue in the peripheral zone.Results The mean values of MK and FA were significantly higher in tumor center than those in normal areas of the peripheral zone,and the ADC values were lower in tumor center,the differences were signicant(P<0.01).ROC curve analysis showed that the AUC of the ADC,FA and MK values were 0.966,0.871 and 0.998,respectively.Conclusion The 3 parameters of DKI could be a potential tool in diagnosing prostate carcinoma in the peripheral zone.The MK value has the highest sensitivity and specificity.