Maintenance Period of Venlafaxine ER Treatment in Patients Having Major Depressive Disorder with Somatic Symptoms / 대한정신약물학회지
Korean Journal of Psychopharmacology
; : 329-337, 2007.
Article
em Ko
| WPRIM
| ID: wpr-62168
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVES:
Medically unexplained physical symptoms comprised the predominant complaints of patients with depression in clinical settings. Previously, tricyclic antidepressants, which inhibit both presynaptic reuptake of serotonin and norepinephrine, had been used to relieve pain as well as treat depression. The objective of this study was to evaluate the efficacy of venlafaxine ER, which also has the effects on both serotonin and norepinephrine, in patients suffering from depression with somatic symptoms.METHODS:
The subjects were recruited from outpatients who had been treated for depression with venlafaxine ER. They were divided into two groups, based on whether they voiced somatic symptoms as their chief complaint (somatic group) or not (non-somatic group). In addition, they were also divided into two groups according to whether they met the criteria of multisomatoform disorder (DSM-IV, Primary Care Version). The duration from the time venlafaxine ER was used to the point when treatment was changed because of the recurrence of symptoms or side effects was assessed and compared using survival analysis in the two groups.RESULTS:
Sixty-four patients fulfilled the inclusion criteria of this study, and 39 patients 'were placed into the somatic group', while the other 25 patients 'were placed into the non-somatic group'. The survival rates of maintenance treatment in the somatic group was significantly higher than in the non-somatic group (logrank test p=0.033), and the mean duration of maintenance treatment in the somatic group was 41.5+/-3.38 weeks, while that in the non-somatic group was 26.0+/-4.95 weeks. When the subjects were classified by the criteria of multisomatoform disorder, no significant difference was observed between the two groups (logrank test p=0.314).CONCLUSION:
In the present study, treatment venlafaxine ER was maintained longer in patients suffering from depression with somatic complaints, which suggests the efficacy of venlafaxine ER on somatic symptoms of these patients. Large-scale, controlled trials are needed to confirm our findings.Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Pacientes Ambulatoriais
/
Atenção Primária à Saúde
/
Recidiva
/
Serotonina
/
Norepinefrina
/
Taxa de Sobrevida
/
Depressão
/
Transtorno Depressivo Maior
/
Cloridrato de Venlafaxina
/
Antidepressivos Tricíclicos
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
Idioma:
Ko
Revista:
Korean Journal of Psychopharmacology
Ano de publicação:
2007
Tipo de documento:
Article