Increased expression of Ets-1 in the diabetic retina of streptozotocin-induced rat model / 国际眼科杂志(Guoji Yanke Zazhi)
International Eye Science
; (12): 19-22, 2007.
Article
em Zh
| WPRIM
| ID: wpr-641705
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WPRO
ABSTRACT
AIM: To determine the involvement of Ets-1 in the pathological progress of the experimental diabetic retina. METHODS: Diabetes was induced by intraperitoneal injection of STZ. Total RNA and Total proteins were isolated from retinas of experimental and control eyes at 4 weeks after STZ-injection and were assessed by Northern blot analysis and Western blot analysis, respectively.RESULTS: Expression of both Ets-1 mRNA and Ets-1 protein was significantly increased in the experimental diabetic rat's retina after STZ-injection compared with the control group (P<0.001).CONCLUSION: Our results indicated that Ets-1 was involved in the pathological progress of experimental diabetic retina.Further studies should be conducted to focus on the relationship between Ets-1 and VEGF in the diabetic retina.
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Zh
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International Eye Science
Ano de publicação:
2007
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Article