Synthesis and quality analysis of sodium 18 F-fluoroacetate and its precursor / 中华核医学杂志
Chinese Journal of Nuclear Medicine
; (6): 259-262, 2011.
Article
em Zh
| WPRIM
| ID: wpr-642394
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WPRO
ABSTRACT
Objective To synthesize and analyze sodium 18F-fluoroacetate (FAC) and its precursor ethyl O-mesylglycolate (EOMG). Methods EOMG was synthesized using modified method. Its chemical purity was checked by HPLC and its structure was elucidated on the basis of spectral analyses. Final product of 18F-FAC was synthesized based on general nucleophilic reactions module Explora GN using EOMG as a precursor. Liquid chromatography Explora LC was applied to get rid of its chemical impurities.Then HPLC and radio-thin layer chromatography were used to assay its radiochemical purity, chemical purity and specific activity. Results EOMG was synthesized and identified. Its yield was 70% and its chemical purity was 97.0% (calculated by chromatographic peak area). The radiochemical purity of 18F-FAC was more than 98%, and its specific activity was 236. 5 MBq/μmol. Conclusion This synthetic method for 18F-FAC and its precursor can be defined as effective and highly quality-controlled.
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WPRIM
Idioma:
Zh
Revista:
Chinese Journal of Nuclear Medicine
Ano de publicação:
2011
Tipo de documento:
Article