Clinical Relevance of High-Resolution Single Nucleotide Polymorphism Array in Patients with Relapsed Acute Lymphoblastic Leukemia with Normal Karyotype: A Report of Three Cases
Annals of Laboratory Medicine
; : 132-136, 2015.
Article
em En
| WPRIM
| ID: wpr-64358
Biblioteca responsável:
WPRO
ABSTRACT
We report three patients with normal karyotype (NK) ALL, who showed genetic aberrations as determined by high-resolution single nucleotide polymorphism array (SNP-A) analysis at both diagnosis and relapse. We evaluated the clinical relevance of the SNP-A assay for the detection of subtle changes in the size of affected genetic lesions at relapse as well as the prognostic value of the assay. In our patients, application of the SNP-A assay enabled sensitive detection of cryptic changes affecting clinically important genes in NK ALL. Therefore, this assay seems to be more advantageous compared to other conventional methods such as FISH assay, HemaVision (DNA Technology, Denmark), and conventional karyotyping for the detection of an "unstable genotype" at relapse, which may be associated with microscopic clonal evolution and poor prognosis. Further comprehensive studies are required to confirm the issues presented by our case patients in this report.
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Índice:
WPRIM
Assunto principal:
Recidiva
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Proteína do Retinoblastoma
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Hibridização in Situ Fluorescente
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Inibidor p16 de Quinase Dependente de Ciclina
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Perda de Heterozigosidade
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Análise de Sequência com Séries de Oligonucleotídeos
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Polimorfismo de Nucleotídeo Único
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Leucemia-Linfoma Linfoblástico de Células Precursoras
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Cariótipo
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Genótipo
Tipo de estudo:
Prognostic_studies
Limite:
Adult
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Female
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Humans
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Male
Idioma:
En
Revista:
Annals of Laboratory Medicine
Ano de publicação:
2015
Tipo de documento:
Article