Effect of Caffeic Acid Phenethyl Ester on Lipopolysaccharide-induced Murine Macrophage Activation / 대한구급학회지
The Korean Journal of Critical Care Medicine
; : 134-138, 2011.
Article
em En
| WPRIM
| ID: wpr-650665
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND: Caffeic acid phenethyl ester (CAPE) is an active component of propolis and is known to have anti-inflammatory properties. This study was performed to evaluate the effects of CAPE on lipopolysaccharide (LPS)-induced murine macrophage activation. METHODS: Raw 264.7 cells were incubated with varying concentrations of CAPE with or without LPS. The production of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta and macrophage inflammatory protein-2 (MIP-2) and activation of extracellular signal-regulated kinases 1/2 (ERK1/2), c-Jun amino terminal kinases (JNK) and p38 were measured. RESULTS: CAPE inhibited the production of TNF-alpha, IL-1beta and MIP-2 and attenuated phosphorylation levels of ERK1/2 and p38, but not JNK in RAW264.7 cells stimulated with LPS. CONCLUSIONS: CAPE can attenuate LPS-induced macrophage responses and we suggest that these effects may play an important role in modulating macrophage-mediated inflammatory responses in vivo.
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Índice:
WPRIM
Assunto principal:
Álcool Feniletílico
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Fosforilação
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Fosfotransferases
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Própole
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Ácidos Cafeicos
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Citocinas
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Interleucinas
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Fator de Necrose Tumoral alfa
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Proteínas Quinases Ativadas por Mitógeno
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MAP Quinases Reguladas por Sinal Extracelular
Idioma:
En
Revista:
The Korean Journal of Critical Care Medicine
Ano de publicação:
2011
Tipo de documento:
Article