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A Interventional Study in a Real Life Setting to Assess the Clinical Efficacy and Effect on Fracture in the 1 Year after Injection of Zoledronic Acid in Osteoporotic Patients with Long Bone or Spine, Pelvic Fractures / 대한정형외과학회잡지
Article em Ko | WPRIM | ID: wpr-651022
Biblioteca responsável: WPRO
ABSTRACT
PURPOSE: We studied the improvement of back pain in vertebral fracture and fracture healing in non-vertebral fracture after treatment with zoledronate in postmenopausal patients. MATERIALS AND METHODS: Postmenopausal women with bone mineral density (BMD) T-score of -2.5 or less and existing vertebral fractures or non-vertebral fractures between January 2011 and June 2012 were included. Patients received a single intravenous infusion of zoledronate within 3 days after diagnosis of fractures. The primary outcome was BMD and secondary outcomes were visual analogue scale (VAS) for back pain, fracture healing, and new clinical fracture. RESULTS: T-score increased significantly in the vertebral fracture group (n=97) and non-vertebral fracture group (n=31) at 1 year (p<0.05). The average VAS for back pain decreased significantly in the vertebral fracture group (p<0.05) and there was no delayed union, nonunion in the non-vertebral fracture group. There was no re-fracture and 3 new clinical fractures (2.34%) occurred during the follow-up period. CONCLUSION: Zoledronate, as treatment in postmenopausal osteoporosis patients can improve BMD, reduce back pain in vertebral fracture, and has no negative effect on bone healing after fracture in non-vertebral fracture.
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Texto completo: 1 Índice: WPRIM Assunto principal: Osteoporose / Coluna Vertebral / Infusões Intravenosas / Densidade Óssea / Osteoporose Pós-Menopausa / Seguimentos / Resultado do Tratamento / Consolidação da Fratura / Dor nas Costas / Diagnóstico Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies Limite: Female / Humans Idioma: Ko Revista: The Journal of the Korean Orthopaedic Association Ano de publicação: 2016 Tipo de documento: Article
Texto completo: 1 Índice: WPRIM Assunto principal: Osteoporose / Coluna Vertebral / Infusões Intravenosas / Densidade Óssea / Osteoporose Pós-Menopausa / Seguimentos / Resultado do Tratamento / Consolidação da Fratura / Dor nas Costas / Diagnóstico Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies Limite: Female / Humans Idioma: Ko Revista: The Journal of the Korean Orthopaedic Association Ano de publicação: 2016 Tipo de documento: Article