Feasibility of radiofrequency ablation for patients with large hepatocellular carcinoma before radical resec-tion / 实用医学杂志

ABSTRACT

Objective To investigate the feasibility of CT-guided radiofrequency ablation for conservative treatment of patients with large hepatocellular carcinoma (LHCC) before radical resection. Methods Patients with secondary large liver cancer were selected as group A(radiofrequency ablation group,n = 27)and group B (surgical treatment group ,n = 33). Liver function ,immunological function ,postoperative complications ,hospi-talization time ,and 3-year relapse-free survival (RFS) were observed between two groups after treatment. Results After treatment,patients′liver function(ALT,AST,ALB,TB),and immune function(CD3+T,CD4+T, CD8+T,CD4+/CD8+,NK,B,Treg)in group A were better than those in group B(P<0.05). There were shorter hospitalization time and lower complication rate in group A when compared with those in group B(P < 0.05)but there was no significant difference regarding to 3-year RFS(P > 0.05). Conclusions Although radiofrequency ablation cannot effectively improve patients′ RFS,but with faster postoperative recovery,less complications,and effective protection for liver function and immune function of patients ,it is a feasible conservative treatment for patients′with LHCC before radical resection.