Study on Inclusion Behavior and Properties of Cordycepin with Hydroxypropyl-β-Cyclodextrin / 分析化学
Chinese Journal of Analytical Chemistry
; (12): 1547-1555, 2017.
Article
em Zh
| WPRIM
| ID: wpr-661425
Biblioteca responsável:
WPRO
ABSTRACT
The inclusion complex of cordycepin ( COR ) with hydroxypropyl-β-cyclodextrin ( HPβCD ) was prepared by the method of saturated solution. The inclusion of HPβCD with COR in aqueous solution was studied by UV-vis spectroscopy, and the inclusion ratio of COR/HPβCD complex was determined with the Job plots. The COR/HPβCD complex was characterized and determined by means of 1 H NMR and 2D NMR, differential scanning calorimetry ( DSC ) , thermogravimetric analysis ( TG ) , X-ray diffraction ( XRD ) , Fourier transform infrared spectroscopy ( FTIR) and scanning electron microscope ( SEM) . The results showed that the COR/HPβCD complex ratio was 1:1 and the water solubility and stability of COR were obviously increased in the inclusion complex with HPβCD. The COR/HPβCD complex will be potentially useful for its medical application.
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Índice:
WPRIM
Idioma:
Zh
Revista:
Chinese Journal of Analytical Chemistry
Ano de publicação:
2017
Tipo de documento:
Article