Influence of fluticasone propionate on pulmonary function, inflammatory factors, endothelial function, and fractional exhaled nitric oxide for patients with stable COPD / 药物评价研究

ABSTRACT

Objective To explore the influence of inhaled corticosteroids on the curative effect and fiactional exhaled nitric oxide and endothelial function for patients with stable COPD.Methods Totally 90 patients with stable COPD were collected in Xinxiang Central Hospital from July 2014 to July 2016,and divided into two groups randomly.The control group (n =45) was treated with conventional Western medicine,the observation group (n =45) were given fluticasone propionate inhalation atomization of 250 g per time,twice daily.The two groups received 6 months of treatment.The pulmonary function indexes including forced vital capacity (FVC),1 s forced expiratory volume (FEV1),maximal mid expiratory flow (MMEF) and peak expiratory flow (PEF),inflammatory factors such as lnterleukin-6 (IL-6),interleukin-8 (IL-8),tumor necrosis factor-α (TNF-α) and C reactive protein (CRP) levels,and vascular endothelial function indexes including flow-mediated vasodilation (FMD),soluble intercellular adhesion molecule-1 (SICAM-1),endothelin 1 (ET-1),and fractional exhaled nitric oxide (FENO) were compared and analyzed.Results After treatment,the pulmonary function indexes were improved significantly (P ＜ 0.05),and the FEV1,FEV1/FVC,MMEF,and PEF of observation group were higher significantly than those patients in control group (P ＜ 0.05).The levels of inflammatory factors decreased than before treatment remarkably (P ＜ 0.05),and the levels of IL-6,IL-8,TNF-α,and CRP in observation group were lower than those in control group,and which difference was significance (P ＜ 0.05).The FMD of patients in study group was higher than those in control group significantly (P ＜ 0.05).The levels of SICAM-1 and ET-1 in observation group were decreased significantly than those before treatment,and were lower than control group (P ＜ 0.05).The FENO of all patients decreased than before treatment,and reduced amplitude in observation group was more than those in control group significantly (P ＜ 0.05).Conclusion Inhaled corticosteroids for patients stable COPD could improve pulmonary functions and inhibit inflammatory response,specially,which improves endothelial function and reduces the amount of exhaled NO and occurrence of cardiovascular events.