Correlation Discussion of Blood Plasma Thromboelastography Values and Antithrombin Ⅲ Level in Children's Kawasaki Disease / 现代检验医学杂志

ABSTRACT

Objective To analyze and discuss the correlations of blood plasma thromboelastography (TEG) values and antithrombin Ⅲ (ATⅢ) level in children's Kawasaki disease (KD).Methods Selected 60 children's KD cases as well as 42 control cases as the KD group,28 children's KD cases with coronary arterial lesions (CAL) as well as 30 children's KD cases without coronary arterial lesions (NCAL) as the CAL group.All cases were archived from January 2015 to February 2017 in Beijing Children's Hospital.The blood plasma TEG parameters were detected by thromboelastography,including blood coagulation time (R),blood clotting time (K),rate of blood clotting (α angle),the maximum intensity of blood clotting (MA),coagulation comprehensive index (CI) and plasma AT Ⅲ level(detected by blood aggregation tester).Results The K (11.1±0.36 min),AT Ⅲ (90.5％ ±[19.05％) and R (5.4± 1.72 min) values were less than those in the control group (2.29±0.66 min,110.4％±10.8％ and 6.85±2.32 min,t=-6.483,-4.267,-3.205,all P＜0.05).CI (2.11±0.70),α angle (75.23°±6.97°) and MA (67.08±6.27 mm) values in the KD group were higher than those in the control group (1.90±0.40,69.65°±5.28° and 59.12±3.52 mm,t=2.339,3.235,4.265,all P＜0.05).InCALgroup,AT Ⅲ (75.5％±9.70％),R (4.40±1.27 min) and K (1.03±0.30 min) values were less than those in the NCAL group (95.6％±12.8％,5.73±1.26 min,1.21± 0.16 min,t=-5.382,-2.731,-2.483,all P＜0.05).MA (70.54± 5.17 mm),CI (2.76±0.38),and α angle (78.79°±2.56°) values in CAL group werehigher than NCAL group (64.37±4.20 mm,2.10±0.49 and 74.43°± 3.03°,t=3.286,4.369,4.759,all P＜0.05).In CAL group,it showed that AT Ⅲ level was positive correlated with R and K values (r=0.495,0.793,P＜0.05) but negative correlated with α angle,MA and CI values (r=-0.422,-0.244 and-0.236,P＜0.05).Conclusion Blood plasma TEG values and AT Ⅲ level has some correlations in children's KD according to our analysis.Combine the two test would be necessary and meaningful in the diagnosis and treatment of children's KD in the future.