Association between IgG N-glycans and Nonalcoholic Fatty Liver Disease in Han Chinese / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
; (12): 454-458, 2018.
Article
em En
| WPRIM
| ID: wpr-690636
Biblioteca responsável:
WPRO
ABSTRACT
Nonalcoholic fatty liver disease (NAFLD) is a major public health issue worldwide. Immunoglobulin G (IgG) N-glycans are associated with risk factors for NAFLD, such as obesity and diabetes. A cross-sectional study involving 500 Han Chinese adults recruited from a community in Beijing was carried out to explore the association between IgG N-glycans and NAFLD. IgG N-glycosylation was significantly associated with NAFLD, with the disease showing a negative correlation with galactosylation (GP14, GP14n, and G2n), positive correlation with fucosylation (FBG2n/G2n), and positive correlation with bisecting N-acetylglucosamine (GlcNAc) [FBG2n/FG2n and FBG2n/(FG2n+FBG2n)], after controlling age, gender, and prevalence of obesity, type 2 diabetes mellitus, hypertension, and hyperlipidemia. In other words, the present study showed a possible association between NAFLD and the loss of galactose and elevations of fucose and bisecting GlcNAc. Aberrant IgG glycosylation might therefore be a potential biomarker for the primary or secondary prevention of NAFLD.
Texto completo:
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Índice:
WPRIM
Assunto principal:
Polissacarídeos
/
Sangue
/
Glicosilação
/
Imunoglobulina G
/
Biomarcadores
/
Razão de Chances
/
China
/
Estudos Transversais
/
Fatores de Risco
/
Diabetes Mellitus Tipo 2
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Limite:
Female
/
Humans
/
Male
País/Região como assunto:
Asia
Idioma:
En
Revista:
Biomedical and Environmental Sciences
Ano de publicação:
2018
Tipo de documento:
Article