Association of interleukin-10 gene polymorphism with bronchial asthma in Chinese subjects in Beijing area / 中国耳鼻咽喉头颈外科

ABSTRACT

OBJECTIVE The objective of this study was to investigate the association between interleukin 10 (IL-10) gene polymorphism and asthma. METHODS We tried to enroll data from 205 asthma patients and 210 controls to investigate the association between IL-10 polymorphisms and asthma in the Han Chinese population. The three common single nucleotide polymorphisms (SNPs), including rs1800896, rs1800871, rs1800872 on the promoter area of IL-10 were genotyped using the sequenom mass array technology platform. RESULTS Our results showed that rs1800872 were significantly associated with asthma. In asthma groups, we found that there was significant high concentration of total serum IgE in genotype AA comparing with genotype CC. CONCLUSION In conclusion, our data showed that rs1800872 was significantly associated with asthma.