Progress of caffeine in preventing bronchopulmonary dysplasia in preterm infants / 国际儿科学杂志

ABSTRACT

Caffeine is a methylxanthine,clinically used to treat apnea in preterm infants. However,it has been found that the drug also has a role in reducing the incidence of bronchopulmonary dysplasia( BPD) in pre-term infants in recent years. It may be related to improvement of lung function,improvement of extubation suc-cess rate and shortening of ventilator assisted ventilation time. Further study found that caffeine could play a pro-tective role in the prevention and control of BPD by antagonistic adenosine receptors, inhibiting inflammatory mediators,inhibiting the transforming growth factors-β1 ,and inhibiting matrix metalloproteinases.