Study on change rule of coagulation related indexes in patients with acute cerebral infarction / 国际检验医学杂志

ABSTRACT

Objective To research the change rule of indexes of thromboelastography (TEG) ,conventional coagulation test and platelet(PLT) count in the patients with acute cerebral infarction .Methods Eighty-two patients with acute cerebral infarction were selected as the disease group and divided into the mild group (35 cases) ,moderate group (30 cases ) and severe group (17 cases ) according to the disease severity .Other 42 healthy subjects undergoing the physical examination were collected as the control group .The TEG indexes (R ,K ,A ,MA) ,conventional coagulation test (PT ,APTT ,FIB) and PLT count were measured .Then the cor-relation analysis was performed .Results Compared with the control group ,R and K in the disease group , mild ,moderate and severe groups the different disease group were decreased ,while A ,MA and FIB were in-creased ,the differences were statistically significant (P<0 .05);K ,A and APTT had statistical difference be-tween the severe group and moderate group(P<0 .05);R was positively correlated with PT ,APTT and PLT (r=0 .606 ,0 .303 ,0 .179 ,P<0 .05);K was positively correlated with PT and negatively correlated with FIB (r=0 .217 ,-0 .212 ,P< 0 .05);A was negatively correlated with PT and positively correlated with FIB (r= -0 .259 ,0 .228 ,P<0 .05);MA was positively correlated with FIB and PLT (r=0 .297 ,0 .165 ,P<0 .05) . Conclusion The blood in the patients with acute cerebral infarction is in hypercoagulable state .Compared with the conventional coagulation test ,TEG can earlier reflect the body′s coagulation function abnormalities and has a certain help for judging the severity of the disease .TEG has a certain correlation with conventional coagulation test indexes and PLT .