The expression and significance of serum P53,MMP-7 and MMP-9 in patients with bladder cancer / 国际检验医学杂志

ABSTRACT

Objective To study the expression and significance of serum P53,MMP-7 and MMP-9 in pa-tients with bladder cancer.Methods From March 2015 to March 2017,104 cases of bladder cancer in our hos-pital were analyzed retrospectively,and 52 patients with benign bladder diseases were selected at the same time.According to the severity of the disease,the patients with bladder cancer were divided into the stage Ⅰ -Ⅱ and stage Ⅲ - Ⅳ,and 52 patients with benign lesions were served as the control group.Serum P53 antibody index and absorption rate,serum matrix metalloproteinase-7(MMP-7),serum matrix metalloproteinase -9 (MMP-9)and urine MMP-7 and MMP-9 levels were compared between the three groups.Results The anti-body level and absorption rate of serum P53 in patients with stage Ⅰ - Ⅱ group and stage Ⅲ - Ⅳ group were higher than those of control group(P<0.05).The index of patients in stage Ⅲ-Ⅳ group is higher than that of stage Ⅰ - Ⅱ group(P< 0.05).The serum levels of MMP-7 and MMP-9 in patients with stage Ⅰ - Ⅱ and stage Ⅲ - Ⅳ were higher than those of the control group(P<0.05).The index of patients in stage Ⅲ - Ⅳgroup is higher than that of stage Ⅰ - Ⅱ group(P<0.05).The urine MMP-7 and MMP-9 water in patients with stage Ⅰ - Ⅱ group and stage Ⅲ - Ⅳ group were higher than those of the control group(P<0.05).The indexes of the patients in stage Ⅲ-Ⅳ group were higher than those in stage Ⅰ - Ⅱ group(P<0.05).Conclu-sion The levels of serum P53 antibody index,MMP-7,MMP-9 and urine MMP-7 and MMP-9 were abnormal in bladder cancer patients.Moreover,the higher the stage of bladder cancer,the higher the expression level of these indicators,w hich are helpful in the early diagnosis of bladder cancer.