Diagnostic value of serum tumor markers in bone metastasis of non-small cell lung cancer / 国际肿瘤学杂志

ABSTRACT

Objective To analyze the diagnostic value of serum tumor markers in bone metastasis of non-small cell lung cancer (NSCLC).Methods The clinical data and follow-up data of 160 patients with NSCLC from March 2013 to September 2015 in Tangshan People's Hospital were retrospectively analyzed.According to the status of bone metastasis,the patients were divided into the observation group with bone metastasis (n =114) and the control group without bone metastasis (n =46).The positive rates and concentrations of 4 tumor markers including carcinoembryonic antigen (CEA),carbohydrate antigen CA125,CA19-9 and Ferritin were analyzed and compared.And their sensitivities and specificities to the diagnosis of NSCLC bone metastasis were analyzed.The Youden index was calculated to capture the performance of the diagnostic test.Results The concentrations of CEA,CA125,CA19-9 and Ferritin in the observation group were (19.74 ±6.71) μg/L,(45.62 ± 19.53) kU/L,(35.89 ± 15.66) kU/L and (334.02 ± 79.43) μg/L respectively,which were higher than those in the control group [(2.36 ± 0.92) μg/L,(14.37 ± 5.43) kU/L,(15.31 ±7.22) kU/L,(122.58 ± 69.46) μg/L],and the differences were statistically significant (t =7.200,P ＜0.001;t=7.180,P＜0.001;t =6.032,P ＜0.001;t=11.152,P＜0.001).The positive rates of CEA,CA125,CA19-9 and Ferritin in the observation group were 78.95％,68.42％,52.63％ and 73.68％ respectively,which were higher than those in the control group (8.70％,4.35％,4.35％ and 13.04％),and the differences were statistically significant (x2 =66.746,P ＜ 0.001;x2=53.822 P ＜ 0.001;x2 =32.193,P ＜0.001;x2 =48.975,P ＜ 0.001).The sensitivities of CEA,CA125,CA19-9 and Ferritin were 78.94％,68.42％,52.63％ and 73.68％ respectively,and the specificities of them were 91.30％,95.65％,95.65％ and 86.96％ respectively.The Youden indexes were 70.24％,64.07％,48.28％ and 60.64％ respectively.The sensitivity and specificity of multi-factorial combination were 99.17％ and 72.63％,and the Youden index was 71.80％.Conclusion Four tumor markers including CEA,CA125,CA19-9 and Ferritin were correlated with NSCLC,and combined detection has better performance of dignosis than single factor.