Virtual screening and preliminary validation of anti-tuberculosis components of traditional Chinese medicine / 国际中医中药杂志
International Journal of Traditional Chinese Medicine
; (6): 534-538, 2018.
Article
em Zh
| WPRIM
| ID: wpr-693642
Biblioteca responsável:
WPRO
ABSTRACT
Objective To verify a method of calculation and prediction by screening the antibacterial components of classical Chinese medicinal herbs (TCM) for anti tuberculosis, and preliminarily evaluate the anti tuberculosis effect of the selected components. Methods The components database of Stemona, Bletilla striata and Chuanbei was established. Dock method was used to predict the anti tuberculosis components from the database, and then mycobacterium smegmatis, MIC and inhibition zone methods were used to evaluate the anti-tuberculosis effect of these predicted components. Results Three ingredients were selected. In vitro experiments also showed that the selected ingredients had the effect of anti-mycobacterium smegmatis by MIC and inhibition zone . Conclusions The virtual screening method could decrease consumption and increase the efficiency of finding anti-tuberculosis ingredients of TCM.
Texto completo:
1
Índice:
WPRIM
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
/
Screening_studies
Idioma:
Zh
Revista:
International Journal of Traditional Chinese Medicine
Ano de publicação:
2018
Tipo de documento:
Article