Risk factors analysis of acute renal failure in patients with ECMO / 临床麻醉学杂志

ABSTRACT

Objective To explore the risk factors of acute renal failure (ARF)in patients with ECMO.Methods Retrospective analysis the patients with ECMO.There were 91 males and 79 fe-males.The age was 18-73 years old.Data of patients'preoperative basic situation(gender,age, history of related diseases,including hypertension,diabetes,heart history),related clinical situations during ECMO period,complications were collected.Patients were divided into two groups according to the ARF occurring.We selected the risk factors which may affect the ARF through the single factor analysis,and then determined the independent risk factors that affected the ECMO ARF by lo-gistic regression analysi.Results This study included 170 cases,91 cases occurred ARF (53.5%). Single factor analysis:the patient with CPR before ECMO,high lactic acid levels pre-ECMO,high inotropic equivalents,large amounts of red blood cells,plasma and platelet transfusion,high C-reac-tive protein levels and high BNP levels during ECMO,long time of ECMO support were associated with patients with ARF.Multiple factors analysis showed that high lactic acid levels pre-ECMO (OR 2.96,95% CI 1.38-6.34),P=0.005),high inotropic equivalents (OR 3.17,95% CI 1.52-6.61, P=0.002)were independent risk factors of ARF in patients with ECMO.Conclusion The patients with ECMO have a high incidence of acute renal failure,large doses of positive inotropic drug and high lactic acid levels are independent risk factors of acute renal failure in patients with ECMO.