Efficacy and Safety of Citric Acid Tandospirone Citrate in the Treatment of Generalized Anxiety Disorder:A Systematic Review / 医药导报
Herald of Medicine
; (12): 368-373, 2018.
Article
em Zh
| WPRIM
| ID: wpr-701016
Biblioteca responsável:
WPRO
ABSTRACT
Objective To systematically review the efficacy and safety of tandospirone in the treatment of generalized anx-iety disorder(GAD) and to provide evidence-based references for clinic. Methods Databases include PubMed,Embase,The Co-chrane Library,CBM,CNKI,VIP and Wanfang Data were electronically searched from the inception to November 2016,to collect randomized controlled trials(RCTs)about the tandospirone citrate in the treatment of generalized anxiety disorder.Meta-analysis was performed by RevMan5.3 software after data extraction and quality evaluation. Results A total of 5 RCTs involving 500 patients were included.The results of Meta-analysis showed no significant differences in the Hamilton Anxiety Scale(HAMA) score between experimental group and control group[MD=0.47,95%CI(-0.51,1.45),P=0.34];and there was no significant differences of total effective rate between experimental group and control group[OR=1.03,95%CI(0.64,1.67),P=0.90].The incidence of adverse reactions in experimental group was significantly lower than that of control group,the difference was statistically significant[OR=0. 65,95%CI(0.44,0.95),P=0.03]. Conclusion Tandospirone citrate,as a new type of non-BZDs of antianxiety drug,shows exact clinical curative effect in the treatment of generalized anxiety disorder with mild adverse reaction and good safety.
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1
Índice:
WPRIM
Tipo de estudo:
Clinical_trials
/
Systematic_reviews
Idioma:
Zh
Revista:
Herald of Medicine
Ano de publicação:
2018
Tipo de documento:
Article