An updated role of astragalosideⅣin heart failure / 中国药理学与毒理学杂志
Chinese Journal of Pharmacology and Toxicology
; (6): 271-272, 2018.
Article
em Zh
| WPRIM
| ID: wpr-705283
Biblioteca responsável:
WPRO
ABSTRACT
Heart failure has become a global public health problem that seriously threatens human health. Due to "multi-target" effect, traditional Chinese medicine has unique advantages in the treat-ment of heart failure. Astragaloside Ⅳ is one of the main active ingredients of astragalus membrana-ceus.It has the functions of protecting the heart and neovascularization,anti-inflammation,anti-oxida-tion, regulating energy metabolism, neuroprotection and anti-cancer effects. This article reviews the recent progresses of astragaloside Ⅳ in the treatment of heart failure.Data show that astragaloside Ⅳcan inhibit heart fibrosis,attenuate excessively activation of renin-angiotensin system,increase energy metabolism, promote positive inotropic action, inhibit myocardial cell apoptosis, etc, which are all involved in the protective role of astragaloside Ⅳ in rodents or cellular models of heart failure.Astragalo-side Ⅳ may be a potential active ingredient in traditional Chinese medicine for the treatment of heart failure.
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Índice:
WPRIM
Idioma:
Zh
Revista:
Chinese Journal of Pharmacology and Toxicology
Ano de publicação:
2018
Tipo de documento:
Article