The role of microRNAs in vascular endothelial cell aging / 中华老年医学杂志

ABSTRACT

Vascular aging may influence the initiation,procession,and severity of various cardiovascular diseases,and thus is one of the most important risk factors for the high mortality of cardiovascular diseases.Vascular endothelial cells are the main cell biological basis of the vasculature,so the structure and function of vascular endothelial cells play a key role in vascular aging.Recently,the association between microRNAs and aging-related diseases has been studied.In this review,we will summarize the role of microRNAs in the process of endothelial cell aging.In addition,we will also discuss possible clinical applications of microRNAs as a diagnostic and therapeutic tool for vascular diseases.