Study on the relationship between metabolic syndrome and intima-media thickness / 中华老年医学杂志

ABSTRACT

Objective To study the relationship between metabolic syndrome (MS) and intimamedia thickness (IMT).Methods Three-hundred and forty-eight elderly male patients with MS were considered as MS group,while 75 cases without MS as a control.The metabolite components,including body mass index (BMI),waist-to-hip ratio (WHR),triglycerides (TG),high-density lipoprotein cholesterol (HDL-C),systolic blood pressure (SBP),diastolic blood pressure (DBP),fasting plasma glucose (FPG) and carotid intima-media thickness (IMT),were compared between groups.The related factors of IMT were analyzed using Pearson correlation analysis and multiple factors Logistic regression.Results In MS group the incidences of carotid artery atherosclerosis [71.6％(249/348) vs.45.3％(34/75),x2=19.155,P=0.000],plaque [53.7％(187/348) vs.33.3％(25/75),x2 =10.274,P=0.001]and unstable plaques [33.0％(115/348)vs.16.0％(12/75),x2 =8.534,P =0.003]were significantly higher than those in the control group.Furthermore,Logistic regression analysis showed that the risk factors for IMT were SBP (OR =1.782,95％ CI1.447-2.195),TG (OR =1.815,95％CI1.528-2.156),FPG (OR=1.921,95％CI1.389-2.657) and HDL-C (OR =0.624,95％CI0.511-0.762).Conclusions The metabolic components can increase the risk of carotid atherosclerosis in elderly male patients with MS,and the risk increases with the degree of carotid artery atherosclerosis.